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Differin Cream or Gel

*price varies with prescription

Differin Cream or Gel

Prescription-strength treatment for severe acne

pros
  • Effective for all types of acne
  • Relatively few side effects
  • More tolerable than other retinoids
cons
  • Mild discomfort may occur at first
  • Not available in a generic version

Experts say that Differin dramatically improves acne, especially when combined with other topical treatments, namely benzoyl peroxide and salicylic acid. Differin is a prescription-strength retinoid, which critics say causes less harsh side effects than other prescription treatments. Researchers also suggest that Differin is more tolerable than other retinoids, tretinoin (Retin-A, Renova) and tazarotene (Tazorac). All retinoids can cause mild side effects, such as burning, peeling, and redness of skin, but experts agree that these effects tend to diminish with continued use. Reviewers say that while Differin is effective for all types of acne, those with mild cases may see similar results by simply using an over-the-counter treatment such as Neutrogena Acne Stress Control 3-in-1 Hydrating Acne Treatment or the Proactiv Solution 3-Step System.

We found the best reviews for Differin in various Dermatology Times articles in which scientific studies are cited as to the efficacy of Differin and other retinoids. Paula Begoun also provides useful information at her website, CosmeticsCop.com, where she recommends Differin and other retinoids based on the science behind them. Good Housekeeping does not rate or compare products in their article entitled Beautiful Skin at Any Age, but does recommend various acne treatments for several different age groups. Reviews posted at Acne.org provide insight into consumer opinion.

Our Sources

1. Dermatology Times

This article cites a study which shows that topical retinoid adapalene gel 0.1 percent (Differin, Galderma) hastens the clearing of acne lesions when used in combination with one or more topical and/or oral treatments. The study involved nearly 2,000 patients and took place over a 12-week period.

Review: "Real-World" Acne Study Documents Benefit of Retinoid-Based Combo TX, Cheryl Guttman, June 2006

2. Dermatology Times

This article documents the results of a study that compared adapalene 0.1%, tazarotene 0.1% and a combination of the two retinoid treatments. While results show that there is no difference in efficacy between the three treatments, adapalene proves to be the least irritating.

Review: Reaching for a Retinoid? Less May be More, Karen Donley-Hayes, April 2007

3. CosmeticsCop.com

Paula Begoun cites scientific studies that prove the efficacy of retinoids for the treatment of acne. She claims that the reactions of each patient will vary and depend greatly upon the relationship of the subject's skin to the particular retinoid. Begoun points out that many patients tend to apply too much to their skin which she says will not provide better or faster results, but "will very likely cause more pronounced side effects."

Review: Prescription Retinoids: Which One to Use?, Paula Begoun

4. Good Housekeeping

The editors of Good Housekeeping magazine recommend prescription-strength retinoids for the treatment of adult acne, but suggest that Retin-A may be too harsh for adult skin. They explain that women in their 30's suffer from hormonal breakouts but are less tolerant of harsh treatments. Editors suggest Differin cream as an alternative because it is less irritating.

Review: Beautiful Skin at Any Age, Editors of Good Housekeeping

5. Acne.org

Consumers posting to Acne.org claim that Differin is very effective at treating acne. While a handful of them did not see any results, the majority seem to be well pleased. Some complain that it is on the expensive side and that it caused minor irritations, but most suggest that given enough time, the treatment is very effective at diminishing blemishes as well as the scars created by acne.

Review: Adapalene (Differin) Reviews, Contributors to Acne.org

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