
Unlike over-the-counter diet products, the prescription appetite suppressant phentermine is approved by the Food and Drug Administration for short-term use in obese people. And because it's been on the market for half a century, physicians are familiar with it and are unlikely to prescribe it for patients who shouldn't be taking this stimulant. However, experts at The Obesity Society say that this prescription medication is no longer prescribed as often because two newer drugs -- orlistat (Xenical) and sibutramine (Meridia) -- can safely be used for longer periods of time. Long-term use of phentermine, which is a relative of amphetamines, could result in addiction. As with any diet product, phentermine use needs to be accompanied by fewer calories and more exercise, experts say.
Mainstream sources like ConsumerReports.org report on diet products but don't rank prescription diet pills like phentermine any more than they'd rate antibiotics. Physicians, not magazines, determine whether a prescription drug is appropriate for you. We found interesting summaries of reports involving phentermine and successful weight loss in lengthy articles on the websites of the Agency for Healthcare Research and Quality and the American Journal of Clinical Nutrition. The Obesity Society also has an interesting comparison between the three major prescription diet drugs, including orlistat, sibutramine and phentermine.
Our Sources
1. Agency for Healthcare Research and Quality
This 128-page PDF about treating obesity refers several times to studies that determine phentermine can be effective for some people.
Review: Screening and Interventions for Overweight and Obesity in Adults, Kathleen McTigue, et al, Dec. 2003
2. American Journal of Clinical Nutrition
This 101-page PDF contains summaries of reports from the newsletter Nutrition Week, including this one about successful weight loss by obese women taking phentermine while limiting caloric intake to 1,200 calories per day.
Review: Effects of Weight Reduction on Body Composition in Postmenopausal Women, Zaida Cordero-MacIntyre, et al, Not Dated
3. The Obesity Society
In this slideshow article, The Obesity Society compares three prescription diet drugs, including phentermine. Overall, they think phentermine was less rigorously tested than the newer weight-loss drugs, including orlistat and sibutramine.
Review: Principles of Pharmacotherapy in the Management of Obesity, Editors of The Obesity Society, 2004-2009
4. WebMD.com
WebMD.com provides a basic synopsis, that Phentermine may or may not work for you. There are more than 1,000 user reviews that give the drug very high average scores and obviously are anecdotal rather than scientific.
Review: Phentermine Oral, Editors of and Contributors to WebMD.com, As of Aug. 2009
5. Mayo Clinic
This brief blurb by a Mayo Clinic dietician warns of possible side effects and says people who take phentermine tend to regain the weight they lose.
Review: Phentermine: Can It Help Me Lose Weight?, Katherine Zeratsky, Oct. 23, 2007
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