Advantage II for Cats Review

Est. $40 and up for a four-month supply
March 2015
by ConsumerSearch
Advantage II for Cats Review

Best flea treatment for cats

  • Kills adult fleas, eggs and larvae
  • Highly effective
  • Side effects are rare
  • No prescription required
  • Leaves greasy residue
Where to Buy

Bottom line

Advantage II for Cats gets consistently high ratings from both vets and cat owners. Though it doesn't work for every cat, it's more consistently effective than any other product. One monthly dose, applied to the back of the cat's neck, kills adult fleas as well as eggs and larvae. Most owners find this flea control easy to apply, but some say it's a bit messy. Side effects are very rare but can be serious.

Breaking it down


Beats the competition. Advantage II for cats contains two key ingredients: imidacloprid, which kills adult fleas, and pyriproxyfen, which stops the growth of flea eggs and larvae. Vets describe Advantage II for Cats as very effective, and most owners agree. Many reviews on pet-product websites specifically note that this product worked when its leading competitor, Frontline Plus for Cats (Est. $35 for a three month supply) failed. However, some owners complain that Advantage II didn't work for their cats or that its effects wore off before the month was out. A few owners say that for them, the original version of Advantage (without pyriproxyfen) works better.


Few problems, but some can be serious. Vets describe Advantage II for cats as a very safe product. Most reviews from cat owners say that this flea control works without causing any side effects; a few even note that it is the only product their pets can tolerate without an adverse reaction. However, we saw a few reports at from owners whose cats suffered side effects -- some serious -- after use. While these problems appear to be extremely rare, it's probably wise to watch your cat closely after using Advantage II and be ready to call the vet if necessary.

Ease of use

No muss, slight fuss. Advantage II comes in single-dose tubes. To apply it, you part the fur at the back of the cat's neck and squeeze out the entire contents of the tube onto the skin. It needs to be applied in a spot the cat can't lick, as ingesting it can cause excessive drooling and hyperactivity. Most owners find Advantage II very easy to apply, although some cats may put up a struggle. The product may leave a greasy spot on the back of the neck; some owners say this dries quickly, while others say it stays wet for days and rubs off on the owner's hands. Most owners don't find the smell bothersome.

Where To Buy
Bayer Advantage II, Kittens, 2 to 5-Pound, 4-Month

8 New from $31.99

In Stock. Eligible for FREE Super Saver Shipping


Advantage II for Cats Reviews


There are more than 2,870 user reviews of Advantage II at this online pet pharmacy, covering both the dog and cat versions of the product. Users give it 4.2 stars out of 5 overall, with 4.2 stars for effectiveness and 4.6 stars for ease of use.

Review: Advantage II, Contributors to, As of March 2015


Advantage II for Cats in its various strengths and dosages receives more than 2,780 user reviews here, with additional reviews at spread across multiple pages. Most cat owners say they find this product effective, fast-working and easy to apply. However, some say it didn't work, and a few complain of dangerous side effects.

Review: Bayer Advantage II Flea Control Treatment for Cats, Contributors to, As of March 2015


We found about 675 reviews of Advantage II for Cats at Its overall rating is 4.6 stars out of 5, and 93 percent of users recommend it. Several users say this is the only flea product that has worked for them without causing harmful side effects.

Review: Advantage II Once-A-Month Cat & Kitten Topical Flea Treatment, Contributors to, As of March 2015

4. All Feline Hospital

Vets at the All Feline Hospital in Lincoln, Neb., list Advantage II for Cats among the best flea treatments available without a prescription. They say the product is "very safe and effective."

Review: Flea Eradication, Staff of All Feline Hospital, Not Dated

5. Mid Hudson Animal Hospital

Vets at Mid Hudson Animal Hospital in Hyde Park, N.Y., recommend the original Advantage as their top pick for flea control in cats, saying it appears to be more effective than Frontline. However, this article does not specifically discuss the current formulation, Advantage II for Cats.

Review: Recommendations for Flea Control, Staff of Mid Hudson Animal Hospital, Not Dated

6. VeterinaryPartner

Veterinarian Carol S. Foil, a specialist in veterinary dermatology, says the original version of Advantage for Cats kills fleas fast and maintains "100% killing" for at least two weeks. She also says that Nylar, the ingredient added to Advantage II for Cats, is "extremely effective against flea eggs."

Review: Flea Control, Carol S. Foil, Not Dated

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