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Diet Pills : Ratings of Sources

By: Kelly Burgess on January 23, 2017

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Diet Pills: Ratings of Sources

Editors of NMCD, As of January 2017

The NMCD is a comprehensive database of most supplement ingredients. Each monogram includes information on what products it's found in, its uses, the effectiveness of its use for various ailments and its safety. In addition NMCD lists any possible interactions between other supplements and medications.

Editors of the National Institutes of Health, April 6, 2015

This report, prepared for health professionals, offers a thorough overview of the most commonly used weight loss supplements; each section details the various studies done on that particular supplements. References to each study are included. Elsewhere on this site, on PubMed.com, the National Library of Medicine which is administrated by the NIH, other articles detail studies done on various weight loss products.

Rohan Khera, MD; Mohammad Hassan Murad, MD, MPH; Apoorva K. Chandar, MBBS, MPH; et al., June 14, 2016

In this meta-analysis of the only five FDA-approved weight loss medications, (trade names Alli/Xenical, Belviq, Qsymia, Contrave and Saxenda) the authors review 28 randomized clinical trials involving 29,018 patients to assess their efficacy. While all five worked to some extent (as did the placebos they were tested against), Qsymia fared best in helping patients lose at least 5 percent of their body weight; about 75 percent.

Kennett, GA and Clifton, PG, November 2010

This review paper looks at the past and current science to see where there are possibilities for new obesity pharmacotherapies. It describes the different physiological aspects of our bodies' abilities to regulate calorie balance. It discusses Lorcaserin, Sibutramine, Orlistat and Phentermine.

NIH Office of Dietary Supplements Staff, As of January 2017

A division of the National Institutes of Health (NIH), the ODS provides fact sheets on a variety of dietary supplements. These fact sheets include basic information on each supplement, such as its use, the research backing it and the side effects associated with it.

Mario A. Inchiosa Jr., Volume 2011

This review compiles information on the adverse events associated with sympathomimetic agents that have been used in weight loss. These agents include amphetamine, phentermine, ephedra, sibutramine, also known as Meridia, and synephrine. While some of these have been effective at aiding weight loss, they have been shown to have serious negative effects on the cardiovascular system, including strokes and irregular heart rhythms.

Luciana Grazziotin Rossato et al., Jan. 2011

This review details the available evidence on synephrine, a popular stimulant used in weight loss. While synephrine is said to be effective at weight loss by thermogenesis, or the production of body heat, very serious side effects have been reported with its use. These include: high blood pressure, irregular heart rhythms, heart attacks and sudden death.

Editors of FDA.com, As of January 2017

The website for the U.S. Food and Drug Administration offers a wealth of information on dietary supplements, including how they are regulated, guidance, alerts and recalls. Elsewhere on this site, the approval processes for prescription diet pills, as well as a detailed overview of the weight loss drugs are available.

Mayo Clinic Staff, April 30, 2015

This informative overview offers the pros and cons of prescription weight loss drugs, including who should consider using them. There is also a helpful overview of the three newest weight loss drugs on the market, Contrave, Belviq and Qsymia.

Kristel Diepvens, Klass R. Westerterp and Margriet S. Westerterp-Plantenga , Jan. 1, 2007

This review article explores the effectiveness, safety and mechanisms of action for caffeine, ephedrine, capsaicin and green tea. While ephedrine is somewhat effective at producing weight loss, its side effects do not make it a feasible option. Capsaicin can be effective, but because of its pungent taste, the dosages are not well tolerated. Caffeine and green tea have shown some efficacy at weight loss, but further research is needed.

Marilyn Barrett and Jay K. Udani, March 17, 2011

This review of Phaseolus vulgaris focuses on the clinical studies conducted on Phase 2 Carb Controller made by Pharmachem Laboratories. Though Pharmachem sponsored this review, it compiles the results of 10 clinical studies. Overall, the use of Phase 2 decreased body weight and body fat in comparison to a placebo, though the weight loss was minimal. Few adverse events were reported, none serious, and most consisted of gastrointestinal complaints such as gas, constipation and diarrhea.

Rebecca Kuriyan et al., May 2007

This study examines the effects of Caralluma fimbriata extract on weight loss, body fat, appetite, and waist circumference, among other measures of obesity. While the extract did not significantly decrease body weight and body fat, it did significantly decrease hunger and waist circumference over the two months of the study.

Suwebatu T. Odunsi et al., Dec. 3, 2009

This clinical study evaluated the effects of CM3 alginate on fullness or satiety after a meal, stomach function and hormones related to feeling full. The study found that there was no difference in satiety, stomach function or satiety hormones with the use of CM3 alginate compared to a placebo. They suggest further research is needed to verify claims by other studies that alginate can help in weight loss.

George A. Bray, Jan. 31, 2008

This article discusses the problem of obesity in the U.S., and the various methods people use to try to lose weight, including exercise, dietary supplements, group programs etc. It details how extensively dietary supplements are used in the U.S., and the drawbacks of not having greater governmental regulation over them.

Soundararajan Kamalakkannan et al., Dec. 28, 2010

This clinical study examines the effects of Caralluma fimbriata extract (CFE) on body weight and fat in rats. When taking CFE, the rats ate less food, had lower body weight and body fat. Though these results are promising, there is no guarantee that similar results would be seen in humans.

Shinobu Mori et al., 2009

While this is an animal study, it is the only research article available on Cirsium oligophyllum. Rats that were given a 10 percent solution of cirsium extract were found to have a moderate reduction in body weight and a substantial reduction in body fat. The effects were enhanced with the addition of caffeine. In addition, the effects of the extract were blocked with the administration of a beta-blocker, confirming the hypothesis that cirsium works via the sympathetic nervous system. While these results are promising, more research is needed as efficacy in rats does not guarantee efficacy in humans.

Ano Lobb, April 14, 2009

This letter to the editor of the World Journal of Gastroenterology provides an overview of the potential for liver damage with some dietary supplements. The author discusses the gaps in establishing the safety of these supplements and previous downfalls, such as with ephedra.

Sherry, B. et al, Aug. 3, 2010

This paper outlines the results of the 2009 Behavioral Risk Factor Surveillance System survey data that the Centers for Disease Control (CDC) used to update estimates of national and state-specific obesity prevalence.

Mayo Clinic Staff, Dec. 19, 2014

This overview lists a few weight loss pill ingredients -- both dietary supplements and pharmaceuticals -- and lists each one's claim, effectiveness and safety. It also gives advice about how to take these substances with your doctor's guidance. Most state that there is not enough data to determine the effectiveness of their ingredients. The authors rely on the U.S. Food and Drug Administration (FDA) and the Natural Medicines Comprehensive Database (NMCD) as their primary sources.

Deborah Pike Olsen, Feb. 3, 2015

In this free-to-the-public article, contributor Deborah Pike Olsen details the results of a survey of nearly 3,000 Americans to measure their knowledge of supplement facts. What the survey found is that many people buy supplements under the assumption that they are regulated like medications, which they are not. Many also do not understand the risk they may be exposing themselves to when they take supplements. Several medical experts are interviewed as well.

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