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Advantage II for Cats Review

By: Carl Laron on April 24, 2018

Bottom Line

Advantage II for Cats gets consistently high ratings from both vets and cat owners. Though it doesn't work for every cat, it's more reliably effective than any other product. One monthly dose, applied to the back of the cat's neck, kills adult fleas as well as eggs and larvae.


  • Kills adult fleas, eggs and larvae
  • Highly effective
  • Side effects are rare
  • No prescription required


  • Leaves greasy residue
Our Analysis
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Breaking it down


Beats the competition. Advantage II for cats contains two key ingredients: imidacloprid, which kills adult fleas, and pyriproxyfen, which stops the growth of flea eggs and larvae. Vets describe Advantage II for Cats as very effective, and most owners agree. Many reviews on pet-product websites specifically note that this product worked when its leading competitor, Frontline Plus for Cats (Est. $35 for a three month supply), failed. However, some owners complain that Advantage II didn't work for their cats or that its effects wore off before the month was out. A few owners say that for them, the original version of Advantage (without pyriproxyfen) works better.


Few problems, but some can be serious. Vets describe Advantage II for cats as a very safe product. Most reviews from cat owners say that this flea control works without causing any side effects; a few even note that it is the only product their pets can tolerate without an adverse reaction. However, we saw a few reports at Amazon from owners whose cats suffered side effects -- some serious -- after use. While these problems appear to be extremely rare, it's probably wise to watch your cat closely after using Advantage II and be ready to call the vet if necessary.

Ease of use

No muss, slight fuss. Advantage II comes in single-dose tubes. To apply it, you part the fur at the back of the cat's neck and squeeze out the entire contents of the tube onto the skin. It needs to be applied in a spot the cat can't lick, as ingesting it can cause excessive drooling and hyperactivity. Most owners find Advantage II very easy to apply, although some cats may put up a struggle. The product may leave a greasy spot on the back of the neck; some owners say this dries quickly, while others say it stays wet for days and rubs off on the owner's hands. Most owners don't find the smell bothersome.

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