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Advantage II for Dogs Review

By: Carl Laron on April 24, 2018

Bottom Line

Advantage II for Dogs contains two ingredients, one that kills adult fleas and one that prevents immature fleas from developing. Dog owners find it more effective than other topical flea treatments, and they say side effects are rare. Its chief drawback is that it doesn't kill ticks.


  • Kills adult fleas, eggs and larvae
  • Highly effective
  • Side effects are rare
  • No prescription required


  • Leaves greasy residue
  • Doesn't kill ticks
Our Analysis
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Breaking it down


Not perfect, but better than most. . Most dog owners find Advantage II for Dogs very effective saying it works fast to wipe out fleas. Many say that this product worked when Frontline Plus for Dogs (Est. $35 and up for a three month supply) failed. However, some reviewers complain that this flea treatment was ineffective or stopped working before the month was up, requiring an extra dose. A few owners say Advantage II used to work for their dogs but no longer does. However, most veterinarians don't report similar results and veterinarian dermatologist Jon Plant says that "the Advantage line of products are generally very effective for flea control in most situations, when used as directed (monthly)."


Side effects are rare. We saw thousands of reviews for Advantage II from dog owners at various pet-product stores, and the vast majority of them say this product had no side effects. Only a handful of owners at Amazon say that their dogs had bad reactions to the drug, typically involving vomiting and diarrhea. It is important to keep the fluid out of the dog's eyes and mouth -- and out of your own as well. The product insert says to wash your hands thoroughly after applying and to call poison control if it's swallowed or gets in your eyes.

Ease of use

Leaves a greasy spot. Advantage II comes in a single-dose tube that you squeeze onto the dog's skin. Small dogs get the entire dose between the shoulder blades; on larger dogs, it's applied at three or four points along the back. In the reviews we consulted, owners don't describe any problems applying it to their dogs. However, a few complain that it leaves a persistent, greasy residue on the dog's fur.

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